Download PrimeHack Updater & place the exe in the Primehack folder. Prime Hack needs to make its own dolphin folder so this will save you from more work if it doesn’t interfere with your own folder.ģ. If you’ve used Dolphin before: Navigate to c:users/(you)/documents & rename the folder called ‘Dolphin Emulator’ to something like ‘Dolphin Emulator backup’. Download Prime Hack.zip, unzip & place the folder where you want.Ģ. At the bottom of this page is also a guide to improving performance and glitches. **OFFICIAL instructions**, these will be updated more frequently than my typed out instructions. Not just a simple config file, shiiion has a SEPARATE VERSION of Dolphin used for this.Ĭontroller profiles: **OUTDATED**, PrimeHack now has a default profile built in! No need to download the controller profiles anymore. How to play Metroid Prime Trilogy via shiiion’s modified version of Dolphin. This story was originally published by the Michigan Health Lab Blog on July 3, 2018.This is an updated video about this mod. Researchers hope to bring this concept to the clinic in the next few years.ĭisclosure: Wicha holds equity in OncoMed Pharmaceuticals. Researchers are also understanding that the immune system is regulated by metabolism, suggesting the possibility of combining anti-stem cell therapies with immunotherapies. “Rather than just try to use toxic chemicals to kill a cell, we use the metabolism of the cell itself to kill the cancer,” Wicha says. Results are published in Cell Metabolism. They tested this in mice with breast cancer and found they could knock out the stem cells. They used a drug currently used to treat arthritis that’s known to block mitochondria, and they manipulated glucose to block that path. So researchers attacked the metabolism in both ways. In the dormant state, the cells use glucose in the proliferative state, they depend on oxygen. It turns out the cell metabolism controls this change, suggesting a possible way in to attack the stem cells.Ĭells get energy through mitochondria, which depends on oxygen, and through sugar, or glucose. “This tells us we’re going to need multiple stem cell therapies to attack multiple forms of stem cells,” he says. They change form to evade the targeted therapy,” says Wicha, Madeline and Sidney Forbes professor of oncology and director of the Forbes Institute for Cancer Discovery at the Rogel Cancer Center. A lot of that resistance is from the cancer stem cells. “When we use targeted therapies, they often only work for a certain period of time, and then the cancer becomes resistant. This plasticity is responsible for cancer’s two key characteristics: multiplying and spreading. Now, researchers have found that cancer stem cells exist in more than one state and are very plastic, meaning they can change form, sliding back and forth between a dormant state and a rapidly growing state. Strike it down in one place, and it pops back up in another. Kill the stem cells, and you could master the cancer.īut cancer is like a game of whack-a-mole. Wicha, M.D., and colleagues discovered that a small number of cells within a tumor - the cancer stem cells - were responsible for fueling the growth and spread of cancer. Researchers at the University of Michigan Rogel Cancer Center are unraveling a crucial thread that explains why cancer so often becomes resistant to treatment.
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